Exosomes as mediators of metastasis

外泌体作为转移介质

• 批准号: nhmrc : 1068510
• 负责人: A/Pr Andreas Moeller
• 金额: $ 27.36万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exosomes-mediators-metastasis/455349
• 关键词: Exosomes; mediators; metastasis

Tumours secrete factors which are contained in specific structures called exosomes, and are used to prepare other organs of the body for subsequently incoming tumour cells, thereby facilitating the often mortal spread of the cancer. This project will investigate the way exosomes alter organs before tumour cells arrive, the composition of these exosomes in lung cancer patients and if they are novel markers for diseases progression as well as therapeutic intervention.

肿瘤分泌包含在称为外泌体的特定结构中的因子，并用于为随后进入的肿瘤细胞准备身体的其他器官，从而促进癌症的致命扩散。该项目将研究外来体在肿瘤细胞到达之前改变器官的方式，这些外来体在肺癌患者中的组成，以及它们是否是疾病进展和治疗干预的新标志物。