Sympathetic Nervous System Regulation of the Tumour Microenvironment

交感神经系统对肿瘤微环境的调节

• 批准号: nhmrc : 1008865
• 负责人: A/Pr Andreas Moeller
• 金额: $ 26.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sympathetic-nervous-regulation-tumour-microenvironment/109350
• 关键词: Sympathetic; Nervous; System; Regulation; Tumour

Metastasis is the major cause of morbidity and mortality in breast cancer. These studies will evaluate the translational opportunity of targeting the sympathetic nervous system as a common regulator of cancer progression pathways. By exploiting sensitive imaging technology for non-invasive, real-time assessment of stress biology, these studies will define the neuroendocrine mechanisms that operate in the tumour microenvironment to support dissemination and arrest of cancer cells in target organs.

转移是乳腺癌发病和死亡的主要原因。这些研究将评估靶向交感神经系统作为癌症进展途径的常见调节剂的转化机会。通过利用敏感的成像技术对应激生物学进行非侵入性实时评估，这些研究将定义在肿瘤微环境中运行的神经内分泌机制，以支持癌细胞在靶器官中的传播和阻滞。