The role chromatin remodeling factors in epigenetic regulation of cardiac arrhythmia

染色质重塑因子在心律失常表观遗传调控中的作用

• 批准号: nhmrc : 1042416
• 负责人: A/Pr Graham Neely
• 金额: $ 56.95万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-chromatin-remodeling-cardiac-arrhythmia/111462
• 关键词: role; chromatin; remodeling; factors; epigenetic

Cardiovascular diseases kill an Australian every 11 minutes. Arrhythmias are of particular alarm since they can lead to significantly higher risk of serious strokes, heart failure, and overall mortality. We combine fruit fly genetics with next generation human genomics approaches to find and functionally validate new genes and mutations regulating arrhythmia in fruit flies and atrial fibrillation in humans, and this work can rapidly identify new avenues to pursue therapeutic intervention

每11分钟就有一名澳大利亚人死于心血管疾病。心律失常尤其令人担忧，因为它们可能导致严重中风、心力衰竭和总死亡率的显著增加。我们将果蝇遗传学与下一代人类基因组学方法相结合，以发现并在功能上验证调控果蝇心律失常和人类心房颤动的新基因和突变，这项工作可以迅速找到寻求治疗干预的新途径。