Transcriptional regulation of nociceptor function and extreme genetic pain disease

伤害感受器功能和极端遗传性疼痛疾病的转录调控

• 批准号: nhmrc : 1107514
• 负责人: A/Pr Graham Neely
• 金额: $ 69.31万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-nociceptor-pain-disease/662988
• 关键词: Transcriptional; regulation; nociceptor; function; extreme

Disorders involving untreatable pain have a devastating impact on a patient’s quality of life. To better treat these conditions, we require a basic understanding of how sensory neurons work. In this study we will define the genetic network involved in regulating pain-sensing neurons. We will then search the genome of pain patients looking for coding mutations within this pain transcriptional network, and we will prove these mutations are causative in fly and mouse systems.

涉及无法治疗的疼痛的疾病对患者的生活质量具有毁灭性的影响。为了更好地治疗这些疾病，我们需要对感觉神经元如何工作有基本的了解。在这项研究中，我们将定义参与调节痛觉神经元的遗传网络。然后，我们将搜索疼痛患者的基因组，寻找疼痛转录网络中的编码突变，我们将证明这些突变在苍蝇和老鼠系统中是致病的。