Functional genomics approach to extend lifespan while preventing age-related cognitive decline

功能基因组学方法可延长寿命，同时防止与年龄相关的认知能力下降

• 批准号: nhmrc : GNT1106902
• 负责人: A/Pr Graham Neely
• 金额: $ 77.26万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-genomics-approach-cognitive-decline/1346543
• 关键词: Functional; genomics; approach; extend; lifespan

In our ageing population, preventing age-related neurological decline is one of the central medical challenges of the 21st century. Here we use human population data obtained from people who reached 90 years of age free of any disease, or patients who suffer from dementia, combined with functional genomics studies in animals to pinpoint new genes that can be targeted to extend lifespan while preserving neurological function in these extended years of life.

在我们的老龄化人口中，预防与年龄相关的神经功能衰退是21世纪世纪的主要医学挑战之一。在这里，我们使用从没有任何疾病的90岁以上的人或患有痴呆症的患者中获得的人口数据，结合动物的功能基因组学研究，以确定可以靶向延长寿命的新基因，同时在这些延长的生命中保留神经功能。