Role of dendritic cell subsets in the generation of CD4 T cell memory

本项目研究由疫苗产生的免疫记忆的建立机制，并确定其有效性。我们的目标是识别和研究以前未被承认的严重影响疫苗接种效果的因素。这一结果将对预防和治疗性疫苗接种（癌症、自身免疫）具有重要意义，并将帮助我们设计新的疫苗来改善感染、自身免疫和癌症的免疫功能。

This project studies the mechanisms responsible for establishing immunologic memory that is generated by vaccination and determines its efficacy. We aim to identify and study previously unacknowledged factors that critically affect the efficacy of vaccination. The results will be significant for both preventative and therapeutic vaccination (cancer, autoimmunity) and will help us to design new vaccines to improve immune function in infection, autoimmunity and cancer.