Role of dendritic cell subsets in the generation of CD4 T cell memory

树突状细胞亚群在 CD4 T 细胞记忆生成中的作用

• 批准号: nhmrc : 570772
• 负责人: Dr Elena Shklovskaya
• 金额: $ 37.58万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dendritic-cell-cell-memory/96732
• 关键词: Role; dendritic; cell; subsets; generation

This project studies the mechanisms responsible for establishing immunologic memory that is generated by vaccination and determines its efficacy. We aim to identify and study previously unacknowledged factors that critically affect the efficacy of vaccination. The results will be significant for both preventative and therapeutic vaccination (cancer, autoimmunity) and will help us to design new vaccines to improve immune function in infection, autoimmunity and cancer.

该项目研究负责建立由疫苗接种产生的免疫记忆并确定其效力的机制。我们的目标是确定和研究以前未被承认的因素，这些因素严重影响疫苗接种的效果。这些结果对于预防性和治疗性疫苗接种（癌症，自身免疫）都具有重要意义，并将帮助我们设计新的疫苗，以改善感染，自身免疫和癌症的免疫功能。