Strategies to enhance CD4 T cell-mediated anti-tumour immunity

增强 CD4 T 细胞介导的抗肿瘤免疫的策略

• 批准号: nhmrc : 1012930
• 负责人: Dr Elena Shklovskaya
• 金额: $ 35.31万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/strategies-enhance-cd4-tumour-immunity/109689
• 关键词: Strategies; enhance; CD4; cell; mediated

The immune system is capable of controlling cancer, but frequently does not do so. In this project we will study two factors that compromise anti-cancer immune responses: regulatory T cells, which suppress immune responses, and tolerogenic dendritic cells, which subvert potentially beneficial responses to tumours. By manipulating these factors, we hope to enhance the effectiveness of the immune response against cancer.

免疫系统能够控制癌症，但通常不会这样做。在这个项目中，我们将研究两个影响抗癌免疫反应的因素：抑制免疫反应的调节性T细胞和破坏对肿瘤的潜在有益反应的致耐受性树突细胞。通过操纵这些因素，我们希望增强免疫反应对抗癌症的有效性。