The role of DNA sensing in the pathogenesis of colorectal cancer

DNA传感在结直肠癌发病机制中的作用

• 批准号: nhmrc : GNT1146864
• 负责人: Dr Si Ming Man
• 金额: $ 62.5万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dna-sensing-colorectal-cancer/1348791
• 关键词: role; DNA; sensing; pathogenesis; colorectal

Colorectal (bowel) cancer is a leading cause of death in Australia and worldwide. The ability of the body to detect DNA from damaged or dying cells in the gut is an important part of the healing process. This response also provides protection against colorectal cancer. In this project, we investigate how a DNA sensor prevents the development of intestinal tumours. This project will lead to new ways to fight cancer in humans.

在澳大利亚和全世界，结直肠癌是主要的死亡原因。身体从受损或死亡的肠道细胞中检测DNA的能力是愈合过程中的一个重要部分。这种反应也提供了对结直肠癌的保护。在这个项目中，我们研究了DNA传感器如何防止肠道肿瘤的发展。该项目将带来抗击人类癌症的新方法。