Type I interferon signalling in bacterial infection

细菌感染中的 I 型干扰素信号传导

• 批准号: nhmrc : GNT1141504
• 负责人: Dr Si Ming Man
• 金额: $ 73.83万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/type-i-interferon-bacterial-infection/1348380
• 关键词: Type; interferon; signalling; bacterial; infection

Infectious diseases are a leading cause of death in Australia. Activation of disease-fighting inflammasomes sets in motion rapid immune defenses against pathogens. In this project, we explore how cell-cell communication molecules known as type I interferons communicate with inflammasomes to achieve the best outcome in the body in response to deadly bacterial infection. Understanding how these signals communicate with one another could reveal new ways to fight infectious diseases.

在澳大利亚，传染病是导致死亡的主要原因。抗病炎症体的激活启动了针对病原体的快速免疫防御。在这个项目中，我们探索了细胞间通讯分子（称为I型干扰素）如何与炎性小体通讯，以在体内对致命细菌感染做出最佳反应。了解这些信号如何相互交流可以揭示对抗传染病的新方法。