The role of EBV and HHV-6 infection in demyelinating disease with a consideration of past UVR exposure.

考虑到过去的 UVR 暴露，EBV 和 HHV-6 感染在脱髓鞘疾病中的作用。

• 批准号: nhmrc : 316901
• 负责人: Prof Anne-Louise Ponsonby
• 金额: $ 20.39万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ebv-hhv-uvr-exposure/77728
• 关键词: role; EBV; HHV; infection; demyelinating

The marked increase in immune disorders over the past fifty years is thought to reflect modern environmental and lifestyle factors, rather than changes in diagnosis. The hypothesis that has the most evidence to support it is the 'hygiene hypothesis'. That is, that a reduction in early life infection among modern children leads to immune system dysfunction and thus an increase in immune disorders. Delayed child infection, particularly of Epstein-Barr Virus has been prospectively linked to multiple sclerosis (MS) risk. This project aims to document the role of herpes virus (EBV, HHV-6) infection in the onset of first demyelinating events, a precursor to MS. The strength of this proposal is that it lies within an existing study framework - the Ausimmune Study, allowing detailed exploration of related associations with latitude, early life infant contact and past sun exposure. The incidence of MS has doubled from 1.2-100,000 to 2.4-100,000 from 1961 to 1996 in Newcastle, Australia. Although incidence is low, the disease has a median age of first onset of 24 years and progresses to serious disability even with immunomodulatory therapy (50% will need assistance in walking within 13 years) thus the current prevalence of 1 per 1,000 adults in Tasmania and 0.8 per 1,000 in Newcastle represent a serious burden of morbidity.

免疫疾病在过去50年中的显著增加被认为反映了现代环境和生活方式因素，而不是诊断的变化。有最多证据支持它的假说是“卫生假说”。也就是说，现代儿童早期感染的减少会导致免疫系统功能障碍，从而增加免疫紊乱。儿童迟发性感染，特别是爱泼斯坦-巴尔病毒，可能与多发性硬化症(MS)的风险有关。该项目旨在记录疱疹病毒(EBV，HHV-6)感染在首次脱髓鞘事件发生中的作用，疱疹病毒是多发性硬化症的先兆。这项建议的优点是，它位于现有的研究框架-Ausimmune研究范围内，允许详细探索与纬度、早期婴儿接触和既往阳光暴露的相关联系。从1961年到1996年，澳大利亚纽卡斯尔多发性硬化症的发病率增加了一倍，从1.2-10万增加到2.4-10万。虽然发病率很低，但该病首次发病的中位年龄为24岁，即使接受免疫调节治疗(50%的人在13年内需要辅助行走)，也会进展为严重残疾。因此，塔斯马尼亚州目前的发病率为每1000名成年人中有1人，纽卡斯尔为每1000人中有0.8人，这是严重的发病率负担。