A POPULATION-BASED COHORT INVESTIGATION OF LUNG FUNCTION IN RELATION TO EARLY LIFE LOWER RESPIRATORY TRACT ILLNESS AND AEROALLERGN SENSITISATION

基于人群的肺功能与早期下呼吸道疾病和空气过敏致敏相关的队列研究

• 批准号: nhmrc : 1009044
• 负责人: Prof Anne-Louise Ponsonby
• 金额: $ 30.41万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/population-based-cohort-aeroallergn-sensitisation/109368
• 关键词: POPULATION; BASED; COHORT; INVESTIGATION; LUNG

Infancy appears to be the critical developmental window during which important alterations in lung structure and function develop. In this study we will assess how early lung function evolves in relation to potential insults such as lower respiratory tract infections and allergic inflammation. These are the mechanisms by which asthma is thought to develop. We will use exciting new lung function tests to evaluate lung function abnormalities associated with peripheral dysfunction characteristic of chronic airway disease such as asthma.

婴儿期似乎是肺结构和功能发生重要变化的关键发育窗口。在这项研究中，我们将评估早期肺功能如何演变与潜在的侮辱，如下呼吸道感染和过敏性炎症。这些都是哮喘被认为是发展的机制。我们将使用令人兴奋的新的肺功能测试来评估与慢性气道疾病（如哮喘）的外周功能障碍特征相关的肺功能异常。