A population-based cohort investigation of postnatal microbial experience, immune programming and allergic disease risk

基于人群的出生后微生物经验、免疫规划和过敏性疾病风险的队列研究

• 批准号: nhmrc : 607370
• 负责人: Prof Anne-Louise Ponsonby
• 金额: $ 100.78万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/population-based-cohort-disease-risk/77804
• 关键词: population; based; cohort; investigation; postnatal

This is a population-based longitudinal investigation of the early life host-environment interactions that influence development of the immune system, and the risk of allergic disease. Importantly, this is one of the first studies designed to examine epigenetic programming of the infant immune system in the population setting. Thus we will be able to conduct robust tests of several critical hypotheses that will inform the prevention of allergic disease.

这是一项基于人群的纵向调查，研究早期宿主-环境相互作用对免疫系统发育和过敏性疾病风险的影响。重要的是，这是第一个旨在研究人群中婴儿免疫系统表观遗传编程的研究之一。因此，我们将能够对几个关键假设进行强有力的测试，这将为过敏性疾病的预防提供信息。