The Role of Med12, a subunit of RNA polymerase II mediator, in haemopoiesis

RNA 聚合酶 II 介质亚基 Med12 在造血中的作用

• 批准号: nhmrc : 516750
• 负责人: Dr Judith Layton
• 金额: $ 33.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-med12-subunit-mediator-haemopoiesis/82401
• 关键词: Role; Med12; subunit; RNA; polymerase

In a screen of zebrafish for mutations in blood cell development, we isolated a mutant called syrah. The mutation causing the blood defect was identified in a gene called med12, which encodes a component of the RNA transcription machinery in cells. To understand how this mutation causes a reduction in blood cells, we will identify the proteins that interact with the med12 protein. Understanding the pathway involved may lead to the discovery of new causes of human congenital blood diseases.

在对斑马鱼血细胞发育突变的筛查中，我们分离出一种名为syrah的突变。导致血液缺陷的突变是在一种名为MED12的基因中发现的，该基因编码细胞中RNA转录机制的一个组成部分。为了了解这种突变是如何导致血细胞减少的，我们将确定与MED12蛋白相互作用的蛋白质。了解相关途径可能会导致发现人类先天性血液疾病的新病因。