Molecular mechanisms of action of local anesthetics in the shedding of microparticles from human monocytic cells

局部麻醉剂在人单核细胞脱落微粒中作用的分子机制

• 批准号: 16K15684
• 负责人: Nishioka Akira
• 金额: $ 0.83万
• 依托单位: National Center for Global Health and Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15684/
• 关键词: 単球; マイクロパーティクル; 局所麻酔薬; procoagulant vesicle; bupivacaine; superoxide dismutase; NADPH oxidase; superoxide; 組織因子; 凝固活性; フローサイトメトリー

项目成果

Comparative Effects of Continuous Radio Frequency Current at 50°C and Pulsed RF on Cytotoxicity, Microvesicle Shedding, and mRNA Expression for POMC in Human Monocytic Cells.

50°C 连续射频电流和脉冲 RF 对人单核细胞 POMC 细胞毒性、微泡脱落和 mRNA 表达的影响比较。

• 发表时间: 2016
• 作者: Azma T;Nishioka A;Ito T;Nagasaka H;Matsumoto N.
• 通讯作者: Matsumoto N.

Effects of prolonged pulsed radio frequency current on cytotoxicity, microvesicle shedding, and mRNA expression for proopiomelanocortin (POMC) in human monocytic cells.

长时间脉冲射频电流对人单核细胞中阿片黑皮素原 (POMC) 的细胞毒性、微泡脱落和 mRNA 表达的影响。

• 发表时间: 2016
• 作者: Azma T;Nishioka A;Ito T;Nagasaka H;Matsumoto N.
• 通讯作者: Matsumoto N.

A case series of radio-frequency ablation of lumbar sympathetic trunks as a minimally invasive adjunctive intervention for patients with chronic visceral pain associated with colonic dysmotility.

腰交感干射频消融作为微创辅助干预治疗与结肠运动障碍相关的慢性内脏疼痛患者的病例系列。

• 发表时间: 2016
• 作者: Azma T;Ito T;Nishioka A;Nagasaka H;Matsumoto N.
• 通讯作者: Matsumoto N.

Involvement of superoxide generated by NADPH oxidase in the shedding of procoagulant vesicles from human monocytic cells exposed to bupivacaine

NADPH 氧化酶产生的超氧化物参与暴露于布比卡因的人单核细胞促凝血囊泡的脱落

• DOI: 10.1007/s11239-017-1531-z
• 发表时间: 2017
• 期刊: Journal of Thrombosis and Thrombolysis
• 影响因子: 4
• 作者: Azma Toshiharu;Ogawa Saori;Nishioka Akira;Kinoshita Hiroyuki;Kawahito Shinji;Nagasaka Hiroshi;Matsumoto Nobuyuki
• 通讯作者: Matsumoto Nobuyuki

Are techniques for general anesthesia less invasive than procedures for cataract surgery?

全身麻醉技术是否比白内障手术的侵入性更小？

• DOI: 10.1038/eye.2017.131
• 发表时间: 2017
• 期刊: Eye
• 影响因子: 3.9
• 作者: Azma T;Nishioka A
• 通讯作者: Nishioka A