The Role of mTOR in the Ageing Liver: Implications for Paracetamol Hepatotoxicity

mTOR 在肝脏衰老中的作用：对乙酰氨基酚肝毒性的影响

• 批准号: nhmrc : 1038169
• 负责人: Ms Alice Kane
• 金额: $ 6.17万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-mtor-ageing-paracetamol-hepatotoxicity/111118
• 关键词: Role; mTOR; Ageing; Liver; Implications

Nutritional interventions and a drug that mimics them, Rapamycin, are the only methods that have been shown to delay ageing and age-related diseases. A key protein in the liver called mTOR is the most likely target for the beneficial effects of these interventions. This study aims to characterize the effects of nutritional interventions and rapamycin on mTOR and markers of ageing in the liver. It also examines the effects of these interventions on the risk and mechanisms of developing paracetamol toxicity.

营养干预和一种类似的药物雷帕霉素是唯一被证明可以延缓衰老和与年龄有关的疾病的方法。肝脏中一种叫做mTOR的关键蛋白质最有可能是这些干预措施产生有益效果的目标。本研究旨在描述营养干预和雷帕霉素对肝脏mTOR和衰老标志物的影响。它还检查了这些干预措施对发展扑热息痛毒性的风险和机制的影响。