Investigation of the Molecular Basis of Frailty and Development of Frailty Biomarkers in a Novel Mouse Ageing Model

在新型小鼠衰老模型中研究衰弱的分子基础和衰弱生物标志物的开发

• 批准号: nhmrc : GNT1122542
• 负责人: Ms Alice Kane
• 金额: $ 40.88万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-molecular-basis-ageing-model/1347286
• 关键词: Investigation; Molecular; Basis; Frailty; Development

Frailty is a state of high vulnerability for adverse health outcomes, and the prevalence of frailty increases with increasing age. There is very little known about why frailty develops, and there is also no widely accepted, efficient method of determining if someone is frail. This project will test blood markers for frailty, that will allow for optimization of treatment for older frail people and use mouse models of frailty to learn more about why frailty develops.

虚弱是一种易受不利健康后果影响的状态，虚弱的患病率随着年龄的增长而增加。人们对虚弱的形成原因知之甚少，也没有被广泛接受的有效方法来确定一个人是否虚弱。这个项目将测试血液标记物的虚弱，这将允许优化治疗老年虚弱的人，并使用虚弱的小鼠模型来了解更多关于虚弱发生的原因。