Role of non-transferrin bound iron in iron overload disease

非转铁蛋白结合铁在铁过载疾病中的作用

• 批准号: nhmrc : GNT1078379
• 负责人: A/Pr Deborah Trinder
• 金额: $ 64.85万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-non-transferrin-overload-disease/1345208
• 关键词: Role; non; transferrin; bound; iron

Plasma non-transferrin bound iron (NTBI) levels are elevated in iron overload disorders. Excess NTBI has serious health consequences as it is toxic and may induce cellular dysfunction and injury. We will investigate the molecular mechanisms by which NTBI transport is regulated, the contribution of NTBI to the development of iron overload and its impact on oxidative-mediated liver and heart injury in iron overload conditions associated with Hereditary Haemochromatosis and thalassaemia.

血浆非转铁蛋白结合铁（NTBI）水平升高，在铁超载疾病。过量的NTBI具有严重的健康后果，因为它是有毒的，并可能诱导细胞功能障碍和损伤。我们将研究NTBI运输调节的分子机制，NTBI对铁过载发展的贡献及其对与遗传性血色病和地中海贫血相关的铁过载条件下氧化介导的肝脏和心脏损伤的影响。