Role of non-transferrin bound iron in iron overload disease

血浆非转铁蛋白结合铁（NTBI）水平在铁超载紊乱中升高。过量的NTBI有严重的健康后果，因为它是有毒的，并可能引起细胞功能障碍和损伤。我们将研究NTBI转运调控的分子机制、NTBI对铁超载发展的贡献及其对遗传性血色素沉着病和地中海贫血相关铁超载条件下氧化介导的肝脏和心脏损伤的影响。

Plasma non-transferrin bound iron (NTBI) levels are elevated in iron overload disorders. Excess NTBI has serious health consequences as it is toxic and may induce cellular dysfunction and injury. We will investigate the molecular mechanisms by which NTBI transport is regulated, the contribution of NTBI to the development of iron overload and its impact on oxidative-mediated liver and heart injury in iron overload conditions associated with Hereditary Haemochromatosis and thalassaemia.