Hormone Transport by Alpha-2-Macroglobulin: Novel Roles in Regulating Hormone Activity

Alpha-2-巨球蛋白的激素运输：调节激素活性的新作用

• 批准号: nhmrc : 1128152
• 负责人: A/Pr Deborah Trinder
• 金额: $ 41.16万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hormone-transport-alpha-hormone-activity/948151
• 关键词: Hormone; Transport; Alpha; Macroglobulin; Novel

Alpha-2-macroglobulin is a large protein in the blood known to bind and transport numerous hormones in the circulation. Our previous studies published in BLOOD (2009) and JBC (2013) have discovered an important role for this molecule in the transport and regulation of a peptide hormone. The studies proposed in this application have important implications for understanding new roles of alpha-2-macroglobulin in hormone binding and regulating the activity of hormones in disease states.

α-2-巨球蛋白是血液中的一种大蛋白质，已知能在循环中结合和运输多种激素。我们之前在血液(2009)和JBC(2013)上发表的研究发现，这种分子在多肽激素的运输和调节中发挥着重要作用。本申请中提出的研究对于理解α-2-巨球蛋白在激素结合中的新作用和调节疾病状态下激素的活性具有重要意义。