Regulation of liver iron loading in hereditary haemochromatosis

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Hereditary haemochromatosis is a common iron overload disorder. It affects 1 in 200 Australians causing liver iron overload, fibrosis, cirrhosis and cancer. The severity of liver iron overload in haemochromatosis is variable. In this study we will determine whether factors that are known to regulate iron metabolism such as iron levels, oxidative stress and inflammation modify liver iron transport systems and the degree of liver iron loading in animal models of haemochromatosis.