Defining iron and haem-induced pro-carcinogenic pathways of colorectal cancer

定义铁和血红素诱导的结直肠癌致癌途径

• 批准号: nhmrc : 1007769
• 负责人: A/Pr Deborah Trinder
• 金额: $ 37.76万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-iron-haem-colorectal-cancer/109250
• 关键词: Defining; iron; haem; induced; pro

Colorectal cancer is very common in Western society. Population studies have reported that high consumption iron-containing foods and red meat, the latter being a source of both haem and iron, are risk factors for colorectal cancer. This study will identify the levels of dietary haem and iron that promote colorectal cancer development. Also, it will determine the mechanisms and relative contribution of iron and haem to pro-carcinogenic pathways that result in colorectal cancer.

大肠癌在西方社会很常见。人口研究报告说，高消费含铁食物和红肉，后者是血红素和铁的来源，是结直肠癌的危险因素。这项研究将确定促进结直肠癌发展的膳食血红素和铁的水平。此外，它还将确定铁和血红素对导致结直肠癌的致癌途径的机制和相对贡献。