THE ROLE OF A NOVEL HYALURONIDASE IN THE TURNOVER OF CHONDROITIN SULPHATE GLYCOSAMINOGLYCANS IN CARTILAGE AND BONE

新型透明质酸酶在软骨和骨中硫酸软骨素糖胺聚糖周转中的作用

• 批准号: nhmrc : 157989
• 负责人: Dr Sharon Byers
• 金额: $ 17.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-novel-hyaluronidase-cartilage-bone/78015
• 关键词: ROLE; NOVEL; HYALURONIDASE; TURNOVER; CHONDROITIN

The degradation of complex carbohydrate structures occurs within specialised intracellular organelles (lysosomes). Their degradation occurs in a strictly defined sequence involving initial clipping into intermediate sized fragments which are each then degraded piece by piece from one end. In this proposal we seek to understand the role of a newly defined enzyme in the initial clipping process. This information will aid our understanding of skeletal pathology in a group of genetic disorders in which complex carbohydrate degradation is impaired. In addition due to the widespread location of complex carbohydrates and their fundamental roles in tissue development and growth, the project has wider implications in diverse disease states such as cancer and wound repair.

复杂碳水化合物结构的降解发生在专门的胞内细胞器（溶酶体）内。它们的降解发生在一个严格定义的序列中，包括初始剪切成中等大小的碎片，然后从一端一块一块地降解。在这个提议中，我们试图理解一种新定义的酶在初始剪切过程中的作用。这一信息将有助于我们理解一组复杂碳水化合物降解受损的遗传疾病中的骨骼病理学。此外，由于复杂碳水化合物的广泛存在及其在组织发育和生长中的基本作用，该项目在多种疾病状态（如癌症和伤口修复）中具有更广泛的意义。