Role and potential for therapeutic targeting of dysfunction, oxidative stress and altered metabolism in mitochondria in the pathogenesis of COPD

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Emphysema is a major cause of illness and death and there are no good treatments. It is caused by smoking that induces lung inflammation and disease but how this occurs is not well understood. Cellular respiration can become defective causing oxidative stress, altered metabolism and inflammation. We think that this drives emphysema. We will assess alterations in respiration, oxidative stress and metabolism in emphysema and see if we can reverse these changes with new potential treatments.