Role of primary cilia and PCP proteins in lens development: implications for lens regeneration after cataract surgery

初级纤毛和 PCP 蛋白在晶状体发育中的作用：对白内障手术后晶状体再生的影响

• 批准号: nhmrc : 1003356
• 负责人: Prof Frank Lovicu
• 金额: $ 27.59万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-primary-cilia-cataract-surgery/108921
• 关键词: Role; primary; cilia; PCP; proteins

Cataract extraction is the most common surgical procedure conducted in our hospitals today. Unfortunately, a complication of surgery is the development of a secondary cataract. This is caused by residual lens epithelial cells undergoing a wound healing response that leads to severe scarring and loss of vision. This project will identify the factors that are needed to maintain lens epithelial cells in a normal state so that they can act as stem cells that can be induced to regenerate a new lens that can transmit and focus light as normal.

白内障提取是今天在我们的医院进行的最常见的外科手术。不幸的是，手术的并发症是继发性白内障的发展。这是由残留的透镜上皮细胞经历了伤口愈合反应，导致严重的疤痕和视力丧失。该项目将确定在正常状态下维持晶状体上皮细胞所需的因素，以便它们可以充当干细胞，该干细胞可以被诱导再生一个可以正常传播和聚焦光线的新晶状体。