The Role and Regulation of Phospholipase Isozymes in the Initiation of Human Labour

磷脂酶同工酶在人类分娩启动中的作用和调节

• 批准号: nhmrc : 114106
• 负责人: Prof Greg Rice
• 金额: $ 30.85万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-regulation-phospholipase-human-labour/97550
• 关键词: Role; Regulation; Phospholipase; Isozymes; Initiation

Being born too early is the most significant problem facing contemporary clinical obstetrics in the developed world. Preterm birth is the major cause of ill-health and death in newborns, accounting for 85% of all early infant deaths, not secondary to genetic abnormality. In Australia in 1998, more than 17,000 babies were born too early, of these over 10,000 suffered respiratory complications and 1300 died during the first 21 days of life. Even though the likelihood of a premature baby surviving doubles for every two weeks that birth is delayed (between 23 and 28 weeks of gestation), currently there is no treatment available that reliably delays or prevents premature birth. In order to develop clinically useful treatments and improve pregnancy outcome and the well-being of our newborn, it is essential to understand the mechanisms that start the process of labour and delivery. Thus, the overall aim of this project is to increase our understanding of how human labour is initiated and to identify processes that may be manipulated to delay premature birth. In particular, this project focuses on the role and regulation, of what we believe is, a central and common pathway involved in triggering the birth process. This pathway is a known regulator of inflammatory process in the body. Intriguingly, the process of birth displays many of the hallmarks of an inflammatory reaction. Our pilot studies suggest that this pathway is involved in activation many of the events that occur at the time of birth and that further investigation of its role will provide valuable insights in to what triggers human birth. The specific aims of this project are (i) to develop a better understanding of the mechanisms that initiate human labour and (ii) to identify more effectively ways of prevent preterm birth.

过早出生是发达国家当代临床产科面临的最重要问题。早产是新生儿健康不良和死亡的主要原因，占所有早期婴儿死亡的 85%，并非继发于遗传异常。 1998年，澳大利亚有超过17,000名婴儿过早出生，其中超过10,000名婴儿出现呼吸道并发症，1300名婴儿在出生后21天内死亡。尽管出生每延迟两周（妊娠 23 至 28 周之间），早产儿的存活率就会增加一倍，但目前尚无可靠的治疗方法可以延迟或预防早产。为了开发临床上有用的治疗方法并改善妊娠结局和新生儿的健康，有必要了解启动临产和分娩过程的机制。因此，该项目的总体目标是增加我们对人类分娩如何开始的理解，并确定可操纵以延迟早产的过程。特别是，该项目重点关注我们认为触发出生过程的核心和共同途径的作用和调节。该途径是体内炎症过程的已知调节因子。有趣的是，出生过程显示出炎症反应的许多特征。我们的初步研究表明，这条途径参与了出生时发生的许多事件的激活，对其作用的进一步研究将为触发人类出生的因素提供有价值的见解。该项目的具体目标是（i）更好地了解引发人类分娩的机制，以及（ii）确定更有效的预防早产的方法。