Role of resident endothelial progenitor cells in melanoma vascularisation and progression

常驻内皮祖细胞在黑色素瘤血管形成和进展中的作用

• 批准号: nhmrc : 1085142
• 负责人: A/Pr Kiarash Khosrotehrani
• 金额: $ 63.5万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-resident-endothelial-vascularisation-progression/519062
• 关键词: Role; resident; endothelial; progenitor; cells

Melanoma is one of the most frequent cancers in Australia. Its growth depends on the rpoper delivery of nutrients and oxygen through blood vessels. This requires the formation of new blood vessels as the tumour grows. In this project we intend to understand the origin of the blood vessels that form in tumours and identify the stem cells that support them. We will use proof of principle experiments to determine whether removal of these stem cells allows the regression of melanoma tumours.

黑素瘤是澳大利亚最常见的癌症之一。它的生长依赖于营养和氧气通过血管的快速输送。这需要随着肿瘤的生长形成新的血管。在这个项目中，我们打算了解肿瘤中形成的血管的起源，并识别支持它们的干细胞。我们将使用原理实验的证据来确定去除这些干细胞是否允许黑色素瘤肿瘤的消退。