The role of seipin in adipocyte development and lipid droplet formation

Seipin 在脂肪细胞发育和脂滴形成中的作用

• 批准号: nhmrc : 1027387
• 负责人: Prof Hongyuan Yang
• 金额: $ 25.09万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-seipin-adipocyte-droplet-formation/110564
• 关键词: role; seipin; adipocyte; development; lipid

The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to characterize seipin, which regulate both lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity.

在澳大利亚和其他发达国家，肥胖及其相关疾病的患病率已达到惊人的水平。肥胖的特征是负载脂滴（LD）的完全分化脂肪细胞的积累。我们的目标是表征 seipin，它调节脂滴形成和脂肪细胞分化。我们提出的研究结果可能会提供针对人类肥胖的新治疗策略。