The role of phosphatidic acid in lipid storage and obesity

磷脂酸在脂质储存和肥胖中的作用

• 批准号: nhmrc : 1057852
• 负责人: Prof Hongyuan Yang
• 金额: $ 33.08万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-phosphatidic-acid-storage-obesity/454638
• 关键词: role; phosphatidic; acid; lipid; storage

The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to examine the role of phosphatidic acid in lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity and type II diabetes.

在澳大利亚和其他发达国家，肥胖症及其相关疾病的流行已经达到了令人震惊的程度。肥胖症的特征在于装载有脂滴（LD）的完全分化的脂肪细胞的积累。我们的目的是研究磷脂酸在脂滴形成和脂肪细胞分化中的作用。我们提出的研究结果可能为人类肥胖和II型糖尿病提供新的治疗策略。