Lipid storage and trafficking in human diseases

人类疾病中的脂质储存和运输

• 批准号: nhmrc : 1058237
• 负责人: Prof Hongyuan Yang
• 金额: $ 46.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipid-storage-trafficking-human-diseases/454661
• 关键词: Lipid; storage; trafficking; human; diseases

The proper trafficking and storage of lipids (e.g. cholesterol and fatty acids) are crucial to human health. For instance, aberrant cellular trafficking and distribution of cholesterol is associated with heart and neurodegenerative diseases. Overwhelmed fat storage capacity can cause type II diabetes. This proposal aims to dissect the molecular mechanisms governing lipid storage and trafficking, and to provide novel therapeutic strategies against obesity, heart and neurological diseases.

脂质（如胆固醇和脂肪酸）的适当运输和储存对人类健康至关重要。例如，胆固醇的异常细胞运输和分布与心脏和神经退行性疾病有关。过度的脂肪储存能力会导致II型糖尿病。该提案旨在剖析控制脂质储存和运输的分子机制，并提供针对肥胖、心脏和神经系统疾病的新治疗策略。