Genome wide screening for gene products that regulate the celluar dynamics of lipid droplets

对调节脂滴细胞动力学的基因产物进行全基因组筛选

• 批准号: DP0984902
• 负责人: Prof Hongyuan Yang
• 金额: $ 11.72万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984902
• 关键词: Genome; wide; screening; gene; products

Obesity is a pandemic that if not stopped, will lead to huge social and economic problems in Australia. In essence, the hallmark of human obesity is the accumulation of cellular lipid droplets. This research will benefit Australia by providing a fundamental understanding of how lipid droplets are formed. This will have immediate international impact at the scientific level and will also provide novel targets and strategies for treating obesity. The proposed study will also benefit Australian agriculture by providing strategies to improve oil production from plant seeds.

肥胖是一种流行病，如果不加以制止，将导致澳大利亚巨大的社会和经济问题。从本质上讲，人类肥胖的标志是细胞脂滴的积累。这项研究将通过提供对脂滴如何形成的基本理解而使澳大利亚受益。这将在科学层面产生直接的国际影响，并将为治疗肥胖提供新的目标和策略。这项拟议的研究还将通过提供提高植物种子产油量的战略，使澳大利亚农业受益。