Role of Set7 in diabetes related end-organ injury

Set7在糖尿病相关终末器官损伤中的作用

• 批准号: nhmrc : 1027341
• 负责人: Prof Assam El-Osta
• 金额: $ 60.27万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-set7-diabetes-organ-injury/110560
• 关键词: Role; Set7; diabetes; related; end

Diabetic complications are the major cause of the medical burden of both type 1 and type 2 diabetes. It appears that prior episodes of poor sugar control have a sustained impact by continuing to damage blood vessels and the kidney, this phenomenon is known as metabolic memory. In this study an enzyme called Set 7 which modifies the proteins wrapping DNA is considered to play a central role in this phenomenon and could be a potential target for developing new treatments to reduce the burden of diabetic complications.

糖尿病并发症是1型和2型糖尿病患者医疗负担的主要原因。先前的血糖控制不佳似乎会对血管和肾脏造成持续损害，这种现象被称为代谢记忆。在这项研究中，一种名为Set 7的酶被认为在这种现象中起着核心作用，它可以修饰包裹DNA的蛋白质，并可能成为开发新疗法以减轻糖尿病并发症负担的潜在靶标。