Role of Set7 in diabetes related end-organ injury
Role of Set7 in diabetes related end-organ injury
批准号:
nhmrc : 1027341
负责人:
Prof Assam El-Osta
金额:
$60.27万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Diabetic complications are the major cause of the medical burden of both type 1 and type 2 diabetes. It appears that prior episodes of poor sugar control have a sustained impact by continuing to damage blood vessels and the kidney, this phenomenon is known as metabolic memory. In this study an enzyme called Set 7 which modifies the proteins wrapping DNA is considered to play a central role in this phenomenon and could be a potential target for developing new treatments to reduce the burden of diabetic complications.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
New models of gene regulation in diabetic complications
-
批准号:nhmrc : GNT1154650
-
项目类别:Research Fellowships
-
资助金额:$64.92万
-
财政年份:2019
-
负责人:Prof Assam El-Osta
-
依托单位:
Targeting epigenetic pathways that lead to diabetic complications
-
批准号:nhmrc : GNT1142262
-
项目类别:Project Grants
-
资助金额:$98.99万
-
财政年份:2018
-
负责人:Prof Assam El-Osta
-
依托单位:
Targeting epigenetic pathways that lead to diabetic complications
-
批准号:nhmrc : 1142262
-
项目类别:Project Grants
-
资助金额:$66.93万
-
财政年份:2018
-
负责人:Prof Assam El-Osta
-
依托单位:
The Persisting Vascular Effects of Activation of the Renin-Angiotensin System
-
批准号:nhmrc : GNT1102342
-
项目类别:Project Grants
-
资助金额:$62.85万
-
财政年份:2016
-
负责人:Prof Assam El-Osta
-
依托单位:
Identifying the epigenomic fingerprint of coronary heart disease in Chinese adults with type 2 diabetes
-
批准号:nhmrc : 1113188
-
项目类别:Targeted Calls
-
资助金额:$41.14万
-
财政年份:2016
-
负责人:Prof Assam El-Osta
-
依托单位:
The Persisting Vascular Effects of Activation of the Renin-Angiotensin System
-
批准号:nhmrc : 1102342
-
项目类别:Project Grants
-
资助金额:$43.12万
-
财政年份:2016
-
负责人:Prof Assam El-Osta
-
依托单位:
Epigenetic determinants of nephropathy in adults with type 1 diabetes
-
批准号:nhmrc : 1082572
-
项目类别:Project Grants
-
资助金额:$35.48万
-
财政年份:2015
-
负责人:Prof Assam El-Osta
-
依托单位:
JDRF/NHMRC Diabetes Complications Centre of Research Excellence
-
批准号:nhmrc : GNT1078609
-
项目类别:Centres of Research Excellence
-
资助金额:$250.0万
-
财政年份:2014
-
负责人:Prof Assam El-Osta
-
依托单位:
JDRF/NHMRC Diabetes Complications Centre of Research Excellence
-
批准号:nhmrc : 1078609
-
项目类别:Centres of Research Excellence
-
资助金额:$173.85万
-
财政年份:2014
-
负责人:Prof Assam El-Osta
-
依托单位:
Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy
-
批准号:nhmrc : 1075563
-
项目类别:Targeted Calls
-
资助金额:$30.41万
-
财政年份:2014
-
负责人:Prof Assam El-Osta
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 526681
-
项目类别:NHMRC Research Fellowships
-
资助金额:$47.37万
-
财政年份:2009
-
负责人:Prof Assam El-Osta
-
依托单位:
Role of chromatin remodelling in diabetic renal and vascular complications: in vivo studies
-
批准号:nhmrc : 526685
-
项目类别:NHMRC Project Grants
-
资助金额:$31.65万
-
财政年份:2009
-
负责人:Prof Assam El-Osta
-
依托单位:
Functional Significance of MeCP2 Target Genes in the Pathogenesis of Rett Syndrome.
-
批准号:nhmrc : 457238
-
项目类别:NHMRC Project Grants
-
资助金额:$31.79万
-
财政年份:2007
-
负责人:Prof Assam El-Osta
-
依托单位:
The generlaity of the SWI/SNF regulatory complex in mental health and cardiovascular disease
-
批准号:nhmrc : 367647
-
项目类别:Career Development Fellowships
-
资助金额:$18.14万
-
财政年份:2006
-
负责人:Prof Assam El-Osta
-
依托单位:
Role of epigenetic mechanisms in diabetic vascular complications
-
批准号:nhmrc : 367621
-
项目类别:NHMRC Project Grants
-
资助金额:$29.24万
-
财政年份:2006
-
负责人:Prof Assam El-Osta
-
依托单位:
Characterisation of the anti-apoptotic function of P-glycoprotein and transcriptional regulation of the MDR1 gene.
-
批准号:nhmrc : 350308
-
项目类别:NHMRC Project Grants
-
资助金额:$31.31万
-
财政年份:2005
-
负责人:Prof Assam El-Osta
-
依托单位:
A new paradigm for SWI/SNF chromatin function; the ATPase dependent remodeler is a component of the MeCP2 complex
-
批准号:nhmrc : 268905
-
项目类别:NHMRC Project Grants
-
资助金额:$16.95万
-
财政年份:2004
-
负责人:Prof Assam El-Osta
-
依托单位:
Characterisation of the anti-apoptotic function of P-glycoprotein and transcriptional regulation of the MDR1 gene
-
批准号:nhmrc : 208930
-
项目类别:NHMRC Project Grants
-
资助金额:$21.61万
-
财政年份:2002
-
负责人:Prof Assam El-Osta
-
依托单位:
国内基金
海外基金
登录
查看更多内容
选择性SET7/9抑制剂的设计优化及缺血性脑损伤保护机制
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:昌军
-
依托单位:
SET7通过调控糖酵解和氧化还原稳态参与PE发生发展的作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:唐金花
-
依托单位:
赖氨酸甲基转移酶SET7通过影响低氧诱导的内皮细胞损伤调节子痫前期的发生发展
-
批准号:CSTB2023NSCQ-BHX0056
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2023
-
负责人:唐金花
-
依托单位:
柴黄益肾颗粒通过lncRNA HOTAIR/SET7轴介导的Sulf1组蛋白甲基化干预糖尿病肾病的机制研究
-
批准号:82374226
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:张浩军
-
依托单位:
甲基转移酶set7/9在鱼类抗病毒先天免疫中的作用机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:54万元
-
批准年份:2022
-
负责人:刘兴
-
依托单位:
EZH2与Set7/9介导组蛋白甲基化在TGF-β1/Smads激活EGR1介导瘢痕疙瘩形成中的作用
-
批准号:82072184
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2020
-
负责人:张广
-
依托单位:
高糖通过组蛋白赖氨酸甲基转移酶SET7在促进P.g致病过程中的作用研究
-
批准号:81700986
-
项目类别:青年科学基金项目
-
资助金额:19.0万元
-
批准年份:2017
-
负责人:苗棣
-
依托单位:
SET7/9甲基化转录因子GLI并调控Hedgehog信号通路的机制及功能研究
-
批准号:31671453
-
项目类别:面上项目
-
资助金额:62.0万元
-
批准年份:2016
-
负责人:邬海龙
-
依托单位:
SET7/9-MCAK相互作用调控有丝分裂染色体运动的功能解析
-
批准号:31601097
-
项目类别:青年科学基金项目
-
资助金额:21.0万元
-
批准年份:2016
-
负责人:王文文
-
依托单位:
内质网应激上调SET7/9表达机制及在糖尿病肾病中的作用
-
批准号:31100927
-
项目类别:青年科学基金项目
-
资助金额:22.0万元
-
批准年份:2011
-
负责人:郭艳红
-
依托单位: