Epigenetic determinants of nephropathy in adults with type 1 diabetes

成人 1 型糖尿病肾病的表观遗传决定因素

• 批准号: nhmrc : 1082572
• 负责人: Prof Assam El-Osta
• 金额: $ 35.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-determinants-nephropathy-1-diabetes/518888
• 关键词: Epigenetic; determinants; nephropathy; adults; type

The prevention and successful management of diabetic complications are issues of utmost importance for the health of Australians. We hypothesize that epigenetic pathways partly determine why some individuals with diabetes develop complications of their disease, while others do not, despite a similar duration of diabetes, treatment intensity and mean glucose exposure.

预防和成功管理糖尿病并发症对澳大利亚人的健康至关重要。我们假设表观遗传途径在一定程度上决定了为什么尽管糖尿病持续时间、治疗强度和平均葡萄糖暴露量相似，但有些糖尿病患者会出现疾病并发症，而另一些患者则不会。