Identifying the epigenomic fingerprint of coronary heart disease in Chinese adults with type 2 diabetes

鉴定中国成人 2 型糖尿病冠心病的表观基因组指纹

• 批准号: nhmrc : 1113188
• 负责人: Prof Assam El-Osta
• 金额: $ 41.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-epigenomic-fingerprint-2-diabetes/663241
• 关键词: Identifying; epigenomic; fingerprint; coronary; heart

Once people get diabetes, even good glucose control may be insufficient to prevent its complications. Diabetes results in molecular imprinting contributing to an increased risk of heart disease. We believe it is possible to identify this imprinted risk by a sophisticated analysis of a standard blood sample. Validating this hypothesis will lead to new biomarkers to identify individuals at increased risk of heart attacks as well as new strategies for the prevention and treatment of heart disease.

一旦人们患上糖尿病，即使良好的血糖控制也可能不足以预防其并发症。糖尿病导致分子印迹导致心脏病风险增加。我们相信，通过对标准血液样本进行复杂的分析，有可能识别出这种印记风险。验证这一假设将导致新的生物标志物来识别心脏病发作风险增加的个体，以及预防和治疗心脏病的新策略。