Targeting epigenetic pathways that lead to diabetic complications

针对导致糖尿病并发症的表观遗传途径

• 批准号: nhmrc : GNT1142262
• 负责人: Prof Assam El-Osta
• 金额: $ 98.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-epigenetic-pathways-diabetic-complications/1348438
• 关键词: Targeting; epigenetic; pathways; lead; diabetic

Glucose remains the major cause of complications in diabetes with prior episodes of high glucose having long lasting effects on blood vessels leading to heart attacks, kidney disease and blindness. We have identified an enzyme Set7 which plays a key role in promoting glucose induced injury. By validating this target using drug and molecular approaches we will strengthen the rationale to develop potent inhibitors of this enzyme in order to reduce the major burden of diabetes, its complications.

血糖仍然是糖尿病并发症的主要原因，先前的高血糖对血管有长期的影响，导致心脏病发作、肾脏疾病和失明。我们已经确定了一种酶Set7，它在促进葡萄糖诱导的损伤中发挥关键作用。通过使用药物和分子方法验证这一目标，我们将加强开发这种酶的有效抑制剂的理由，以减少糖尿病及其并发症的主要负担。