A role of sortilin in the development of Alzheimer's disease

分拣蛋白在阿尔茨海默病发展中的作用

• 批准号: nhmrc : 1021408
• 负责人: Prof Xin-Fu Zhou
• 金额: --
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-sortilin-development-alzheimers-disease/662333
• 关键词: role; sortilin; development; Alzheimer; disease

Alzheimer’s disease is the most common form of dementia and is caused by both environmental and genetic variations. With aging, a toxic peptide accumulates in the brain and causes loss of memory and cell death. This study aims to elucidate how the toxic peptide is generated and how its precursor trafficks within nerve cells.

阿尔茨海默病是痴呆症最常见的形式，由环境和遗传变异引起。随着年龄的增长，一种有毒的肽在大脑中积累，导致记忆丧失和细胞死亡。这项研究旨在阐明毒性肽是如何产生的，以及它的前体如何在神经细胞内运输。