Roles of proBDNF in nerve regeneration

proBDNF 在神经再生中的作用

• 批准号: nhmrc : 595937
• 负责人: Prof Xin-Fu Zhou
• 金额: $ 33.09万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/roles-probdnf-nerve-regeneration/76993
• 关键词: Roles; proBDNF; nerve; regeneration

Nerve growth factors are essential to promote nerve regeneration and are potential drugs for the treatment of nervous disorders such as spinal cord injury. Our recent result demonstrates that the precursor form of the nerve growth factor brain derived neurotrophic factor (proBDNF) is detrimental to an injured nervous system and can cause nerve degeneration. This project further investigates the phenomenon in order to promote treatment of spinal cord injury.

神经生长因子对促进神经再生至关重要，是治疗脊髓损伤等神经疾病的潜在药物。我们最近的结果表明，神经生长因子脑源性神经营养因子(ProBDNF)的前体形式对受损的神经系统有害，并可导致神经退化。本课题对这一现象进行了进一步的研究，以期促进脊髓损伤的治疗。