Roles of peripherally derived BDNF in regeneration of spinal cord and the mechanisms

外周源性BDNF在脊髓再生中的作用及其机制

• 批准号: nhmrc : 375109
• 负责人: Prof Xin-Fu Zhou
• 金额: $ 31.52万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/roles-peripherally-derived-cord-mechanisms/76089
• 关键词: Roles; peripherally; derived; BDNF; regeneration

Injury to the brain and spinal cord often leads to permanent disability due to lack of regeneration. The mechanism why central nerve does not regenerate is not known. Neurotrophic factors are powerful molecules which can overcome effects of inhibitory factors on regeneration. This project aims to investigate how neurotrophic factors override the effects of inhibitory factors and how to improve the regeneration by increasing the production of neurotrophic factors within nerves. Successful completion of this project will help understanding the mechanism of how neurotrophic factors work on regeneration and developing the effective way to improve regeneration of the injured spinal cord.

大脑和脊髓损伤往往会导致永久性残疾，因为缺乏再生。中枢神经不能再生的机制尚不清楚。神经营养因子是一种强大的分子，可以克服抑制因子对再生的影响。本项目旨在研究神经营养因子如何克服抑制因子的作用，以及如何通过增加神经内神经营养因子的产生来促进再生。本项目的成功完成将有助于了解神经营养因子对再生的作用机制，并开发促进损伤脊髓再生的有效方法。