Developing a novel therapy for Alzheimers disease

开发阿尔茨海默病的新疗法

• 批准号: nhmrc : 480422
• 负责人: Prof Xin-Fu Zhou
• 金额: $ 36.74万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developing-novel-therapy-alzheimers-disease/95103
• 关键词: Developing; novel; therapy; Alzheimers; disease

Alzheimer's disease is the most common brain disease which has huge social and economical burdens for the modern society. It is caused by accumulation of the toxic peptides, called amyloid beta, in the brain. There is no treatment for this devastated condition. We have identified a fragment of antibody specifically recognizing amyloid beta peptides which dissolves and remove the plaques from the brain. This project is to further test this novel drug in mouse model of the disease.

阿尔茨海默病是最常见的脑部疾病，给现代社会带来巨大的社会和经济负担。它是由被称为淀粉样β蛋白的有毒多肽在大脑中积累引起的。对于这种毁灭性的疾病，没有治疗方法。我们已经识别了一段抗体，专门识别淀粉样β蛋白多肽，这种抗体可以溶解并移除大脑中的斑块。本项目是为了在疾病的小鼠模型上进一步测试这种新药。