The role of steatosis in promoting cellular injury and fibrogenesis in human liver disease

脂肪变性在促进人类肝病细胞损伤和纤维形成中的作用

• 批准号: nhmrc : 351579
• 负责人: A/Pr Julie Jonsson
• 金额: $ 27.63万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-steatosis-promoting-liver-disease/81179
• 关键词: role; steatosis; promoting; cellular; injury

Lay Description Fatty liver (steatosis) is important because it increases the vulnerability of the liver to factors that trigger inflammation and fibrosis. Patients with steatosis may develop steatohepatitis spontaneously and this increases the risk and rate of progression to cirrhosis, with consequent liver-related morbidity and mortality. In addition, steatosis significantly potentiates the severity of liver damage that is caused by other agents such as drugs or infections. To improve the prognosis of patients with fatty livers, it is important to understand why hepatic steatosis increases the risk for more serious liver disease. To date, much of our understanding of mechanisms of liver injury in fatty liver disease comes from animal models, and these findings have not been systematically evaluated in the human disease. Apart from optimizing body weight, there is no established treatment of fatty liver disease. Delineation of the mechanisms involved in liver injury will allow the development of specific protective strategies for steatotic livers.

脂肪肝(脂肪变性)很重要，因为它增加了肝脏对引发炎症和纤维化的因素的脆弱性。脂肪变性的患者可能会自发发展为脂肪性肝炎，这会增加进展为肝硬变的风险和速度，从而导致肝脏相关的发病率和死亡率。此外，脂肪变性显著加剧了由药物或感染等其他因素引起的肝脏损害的严重性。为了改善脂肪肝患者的预后，了解为什么肝脏脂肪变性会增加患更严重肝病的风险是很重要的。到目前为止，我们对脂肪性肝病的肝损伤机制的了解大多来自动物模型，这些发现还没有在人类疾病中得到系统的评估。除了优化体重外，还没有针对脂肪肝的既定治疗方法。阐明肝脏损伤的机制将有助于开发针对脂肪性肝脏的特定保护策略。