Role of obesity in impaired treatment response in chronic hepatitis C: mechanisms and therapeutic strategies

肥胖在慢性丙型肝炎治疗反应受损中的作用：机制和治疗策略

• 批准号: nhmrc : 511201
• 负责人: A/Pr Julie Jonsson
• 金额: $ 36.01万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-obesity-impaired-therapeutic-strategies/78380
• 关键词: Role; obesity; impaired; treatment; response

The overall objective of this Research Project is to examine the mechanisms by which obesity and fatty liver impair the response to antiviral treatment in patients with chronic hepatitis C and to develop specific strategies to monitor and improve the outcome of treatment. In addition, the development of non-invasive strategies and surrogate cell culture systems for the assessment and serial monitoring of the antiviral response will be of substantial benefit.

本研究项目的总体目标是研究肥胖和脂肪肝损害慢性丙型肝炎患者抗病毒治疗反应的机制，并制定具体策略来监测和改善治疗结果。此外，开发用于评估和连续监测抗病毒反应的非侵入性策略和替代细胞培养系统将具有实质性益处。