Monocytes/macrophages in chronic liver diseases: cross-talk with hepatocytes and nonparenchymal cells and role in progressive liver injury

慢性肝病中的单核细胞/巨噬细胞：与肝细胞和非实质细胞的串扰及其在进行性肝损伤中的作用

• 批准号: nhmrc : 1003108
• 负责人: A/Pr Julie Jonsson
• 金额: $ 39.92万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/monocytesmacrophages-chronic-liver-liver-injury/108897
• 关键词: Monocytes; macrophages; chronic; liver; diseases

More than 170 million people world-wide are chronically infected with the hepatitis C virus. Approximately 10-15% of chronically infected subjects develop cirrhosis with its attendant risks of liver failure and hepatocellular carcinoma. The objective of this important project is to examine the mechanisms by which monocytes and macrophages (cells of the immune system) enhance or impair the progression of liver disease and response to antiviral treatment in patients with chronic hepatitis C.

全世界有超过1.7亿人慢性感染丙型肝炎病毒。大约10-15%的慢性感染受试者发展为肝硬化，伴随肝衰竭和肝细胞癌的风险。这个重要项目的目的是研究单核细胞和巨噬细胞（免疫系统细胞）增强或损害慢性丙型肝炎患者肝脏疾病进展和抗病毒治疗反应的机制。