Integrated bacterial genomics and virulence analysis of uropathogenic Streptococcus agalactiae

尿路致病性无乳链球菌的综合细菌基因组学和毒力分析

• 批准号: nhmrc : GNT1146820
• 负责人: A/Pr Scott Beatson
• 金额: $ 73.71万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrated-bacterial-genomics-streptococcus-agalactiae/1348789
• 关键词: Integrated; bacterial; genomics; virulence; analysis

Urinary tract infections (UTI), which start as a bladder infection and often evolve to encompass the kidneys, are among the most common infectious diseases in humans. Streptococcus agalactiae is an important cause of gram-positive bacterial UTI. We will study the genomes and functions of specific genes in reference strains of this bacterium isolated from patients with different forms of infection to elucidate how bacterial genes and virulence factors contribute to these types of infections.

尿路感染（UTI），开始作为膀胱感染，并经常演变为包括肾脏，是人类最常见的传染病之一。无乳链球菌是引起革兰氏阳性菌尿路感染的重要原因。我们将研究从不同感染形式的患者中分离的这种细菌的参考菌株中特定基因的基因组和功能，以阐明细菌基因和毒力因子如何导致这些类型的感染。