The role of thymocyte self-renewal in causing T cell leukaemia

胸腺细胞自我更新在引起T细胞白血病中的作用

• 批准号: nhmrc : 628368
• 负责人: A/Pr David Curtis
• 金额: $ 39.11万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-thymocyte-self-cell-leukaemia/95836
• 关键词: role; thymocyte; self; renewal; causing

Recurrence of acute leukamia after therapy is due to the presence of immature cells that can self-renew, a process that is normally restricted to stem cells. Through the study of mice that develop leukaemia, we have identified these very rare self-renewing cells that are resistant to standard therapies. We can identify and measure these cells many months before leukaemia develops. As such, we will use this mouse model to understand how these cells self-renew and how they can be killed

治疗后急性白血病的复发是由于存在可以自我更新的未成熟细胞，这一过程通常仅限于干细胞。通过对患白血病的小鼠的研究，我们发现了这些非常罕见的自我更新细胞，它们对标准疗法有抵抗力。我们可以在白血病发生前几个月识别和测量这些细胞。因此，我们将使用这种小鼠模型来了解这些细胞如何自我更新以及它们如何被杀死