The role of thymocyte self-renewal in causing T cell leukaemia
The role of thymocyte self-renewal in causing T cell leukaemia
批准号:
nhmrc : 628368
负责人:
A/Pr David Curtis
金额:
$39.11万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Recurrence of acute leukamia after therapy is due to the presence of immature cells that can self-renew, a process that is normally restricted to stem cells. Through the study of mice that develop leukaemia, we have identified these very rare self-renewing cells that are resistant to standard therapies. We can identify and measure these cells many months before leukaemia develops. As such, we will use this mouse model to understand how these cells self-renew and how they can be killed
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会议论文
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批准号:nhmrc : 1139466
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负责人:A/Pr David Curtis
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批准号:nhmrc : GNT1135107
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项目类别:Centres of Research Excellence
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财政年份:2017
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依托单位:
Centre for Blood Transplant and Cell Therapy
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批准号:nhmrc : 1135107
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资助金额:$168.96万
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财政年份:2017
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负责人:A/Pr David Curtis
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依托单位:
Bone marrow Endothelial Stem Cells have the capacity to form both the endothelial and haemopoietic hierarchies
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批准号:nhmrc : GNT1084990
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财政年份:2015
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负责人:A/Pr David Curtis
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依托单位:
Bone marrow Endothelial Stem Cells have the capacity to form both the endothelial and haemopoietic hierarchies
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批准号:nhmrc : 1084990
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依托单位:
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财政年份:2013
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负责人:A/Pr David Curtis
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依托单位:
Endocytosis and asymmetric cell division in leukemia.
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资助金额:$36.56万
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财政年份:2013
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依托单位:
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财政年份:2011
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负责人:A/Pr David Curtis
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Using mouse models to identify better therapies for acute leukemia and myelodysplasia
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批准号:nhmrc : 1003077
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项目类别:Practitioner Fellowships
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资助金额:$0.0万
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财政年份:2011
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负责人:A/Pr David Curtis
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依托单位:
Molecular analysis of myelodysplasia in the Nup98HoxD13 mouse model
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财政年份:2010
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依托单位:
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批准号:nhmrc : 544302
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依托单位:
Understanding the pharmacology of G-CSF for treating myocardial infarction
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资助金额:$28.63万
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财政年份:2008
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依托单位:
Hematopoietic effects of activating the Hedgehog pathway.
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资助金额:$27.38万
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财政年份:2007
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负责人:A/Pr David Curtis
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依托单位:
Analysis of the interaction of the T-cell oncoproteins Scl and Lmo2 in T cell acute lymphoblastic leukaemia
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批准号:nhmrc : 382901
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项目类别:NHMRC Project Grants
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资助金额:$11.95万
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财政年份:2006
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负责人:A/Pr David Curtis
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依托单位:
Characterisation of erythropoietic mutants identified in a forward genetic screen in mice.
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批准号:nhmrc : 382900
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项目类别:NHMRC Project Grants
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资助金额:$33.47万
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财政年份:2006
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依托单位:
The role of bHLH factors in normal and leukemis haemopoiesis
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资助金额:$32.37万
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财政年份:2006
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依托单位:
Regulation of red blood cell and platelet formation by bHLH proteins
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批准号:nhmrc : 332502
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项目类别:NHMRC Project Grants
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资助金额:$28.18万
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财政年份:2005
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Hematopoietic cytokines for the repair of myocardial infarction
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资助金额:$22.3万
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财政年份:2005
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负责人:A/Pr David Curtis
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依托单位:
Charecterisations pf the receptor tyrosine kinase, NYK on early haemopoietic progenitors
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批准号:nhmrc : 997002
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项目类别:Early Career Fellowships
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资助金额:$21.21万
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财政年份:1999
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负责人:A/Pr David Curtis
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依托单位:
海外基金