Bone marrow Endothelial Stem Cells have the capacity to form both the endothelial and haemopoietic hierarchies

骨髓内皮干细胞具有形成内皮和造血层次结构的能力

• 批准号: nhmrc : 1084990
• 负责人: A/Pr David Curtis
• 金额: $ 96.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bone-marrow-endothelial-haemopoietic-hierarchies/519050
• 关键词: Bone; marrow; Endothelial; Stem; Cells

Blood cell formation is hierarchically organised; with hemopoietic stem cells (HSC) responsible for producing mature circulating blood cells. HSC reside in marrow near blood vessel cells. Although these play a key role in HSC regulation their origin in adults is poorly understood. We have demonstrated the existence of adult marrow vessel stem cells at the apex of a parallel hierarchy. Our objective is to characterise these in mice and humans and determine their role in blood malignancies.

血细胞的形成是分层组织的;造血干细胞（HSC）负责产生成熟的循环血细胞。HSC位于骨髓中血管细胞附近。虽然这些在HSC调节中起着关键作用，但对它们在成人中的起源知之甚少。我们已经证明了成人骨髓血管干细胞存在于一个平行层次的顶点。我们的目标是在小鼠和人类中检测这些基因，并确定它们在血液恶性肿瘤中的作用。