Therapeutic targeting of Precancerous Stem Cells in T cell leukaemia

T 细胞白血病癌前干细胞的治疗靶向

• 批准号: nhmrc : 1003391
• 负责人: A/Pr David Curtis
• 金额: $ 44.99万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-targeting-precancerous-cell-leukaemia/108926
• 关键词: Therapeutic; targeting; Precancerous; Stem; Cells

We have recently identified a stem cell population causes T cell leukaemia. These cells may also survive conventional leukaemia therapies and cause relapse. This project will determine whether these stem cells can be killed using conventional leukaemia therapeutics. In addition, we will identify new therapeutic targets to eliminate these cells. This will enable us to specifically target the cells responsible for leukaemia relapse.

我们最近发现了一个干细胞群导致T细胞白血病。这些细胞也可能在传统的白血病治疗中存活下来，并导致复发。该项目将确定这些干细胞是否可以用传统的白血病疗法来杀死。此外，我们将确定新的治疗靶点来消除这些细胞。这将使我们能够专门针对导致白血病复发的细胞。