Using mouse models to identify better therapies for acute leukemia and myelodysplasia

使用小鼠模型寻找治疗急性白血病和骨髓增生异常的更好疗法

• 批准号: nhmrc : 1003077
• 负责人: A/Pr David Curtis
• 金额: --
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Practitioner Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-mouse-models-leukemia-myelodysplasia/108891
• 关键词: Using; mouse; models; identify; better

Despite great advances in the understanding of the genes that cause cancers of the blood, cure rates for patients with acute leukemia, or a more indolent form called myelodyspslaia, has not improved significantly over the last 20 years, with the majority of patients dying from resistant or recurrent disease within 5 years. Our research will use mouse models of acute leukemia and myelodysplasia to identify the critical genetic pathways that drive these diseases and to design and test new therapies that can be taken into clinical trials.

尽管对导致血液癌症的基因的理解有了很大的进步，但急性白血病患者的治愈率，或一种称为骨髓增生异常综合征的更惰性的形式，在过去的20年里没有显着改善，大多数患者在5年内死于耐药或复发性疾病。我们的研究将使用急性白血病和骨髓增生异常的小鼠模型来确定驱动这些疾病的关键遗传途径，并设计和测试可用于临床试验的新疗法。