Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemical proteomics

社区中耐多药细菌的流行是一个关键的公共卫生问题，迫切需要具有新型作用模式的新型抗生素来对抗这些致命的超级细菌。虽然天然抗生素长期以来一直是制药业的支柱，但它们作为药物的发展可能具有挑战性，因为它们的细胞靶点和作用方式往往是未知的。在这个项目中，创新的化学蛋白质组学方法将用于快速识别和表征新发现和历史上的抗生素天然产物的细胞靶点和作用模式，从而克服这一瓶颈，加速下一代抗生素的开发。

The prevalence of multidrug-resistant bacteria in the community is a critical public health issue and there is an urgent and compelling need for new antibiotics with novel modes of action to combat these deadly superbugs. While antibiotics from nature have long been a mainstay of the pharmaceutical industry, their development as drugs can be challenging as their cellular targets and modes of action are frequently unknown. In this project, innovative chemical proteomics approaches will be used to rapidly identify and characterise the cellular targets and modes of action of both newly discovered and historic antibiotic natural products, thereby overcoming this bottleneck and accelerating the development of next-generation antibiotics.