Reverse chemical proteomics: harnessing yeast display for drug discovery

反向化学蛋白质组学：利用酵母展示进行药物发现

• 批准号: DP180102569
• 负责人: A/Prof Andrew Piggott
• 金额: $ 29.29万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-06-04 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102569
• 关键词: Reverse; chemical; proteomics; harnessing; yeast

This project aims to develop a technique that can rapidly identify the cellular protein targets of biologically active natural products. This project expects to provide fundamental biological and chemical insights into Australia's unique biodiversity that will facilitate the development of new therapeutic agents and agrochemicals based on leads provided by Nature. Expected outcomes of this project include an optimised and validated platform technology for accelerating drug discovery and development. This should substantially reduce the costs associated with fighting human and animal diseases, leading to improved health, productivity and quality of life.

该项目旨在开发一种能够快速识别具有生物活性的天然产品的细胞蛋白靶标的技术。该项目预计将为澳大利亚独特的生物多样性提供基本的生物和化学见解，以促进基于自然提供的线索开发新的治疗剂和农用化学品。该项目的预期成果包括用于加速药物发现和开发的优化和验证的平台技术。这将大大减少与抗击人类和动物疾病有关的成本，从而改善健康、生产力和生活质量。