Signalling of muscle force by Golgi tendon organs during exercise and fatigue

运动和疲劳期间高尔基腱器官发出的肌肉力量信号

• 批准号: nhmrc : 194307
• 负责人: John Gregory
• 金额: $ 12.09万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signalling-muscle-force-exercise-fatigue/78230
• 关键词: Signalling; muscle; force; Golgi; tendon

It is a common experience for objects being carried to feel heavier and tasks needing muscular effort to become more difficult as one becomes tired and the muscles fatigue during exertion. The sensation of muscle force depends on two factors. One, a sense of the effort required to perform a task, is generated in the central nervous system and. The other, a sense of the force actually developed by the muscles, is generated in the muscles themselves by signals from sensory receptors called Golgi tendon organs. The sensation of muscle force and the heaviness of objects results from a combination of both senses, but the contribution of each is unknown. The aim of the project is to determine whether the disturbance of force sense in fatigued muscles results from changes in the way tendon organs signal the actual force developed by the muscles. This will be important for understanding how force sense is disturbed following exercise and in disease states, and for understanding the normal way muscle force is sensed in everyday situations. Disturbances of force sense after exercise will be documented in human subjects by asking them to generate what they perceive to be equal forces in both arms or legs, before and after one limb only is exercised. Errors in force estimation will show up as mismatches between the two limbs. The difficulty with human experiments is that the signals generated by tendon organs cannot be measured directly, but only inferred, perhaps wrongly. This difficulty will be overcome by measuring tendon organ activity directly in anaesthetised animals, where the muscles will be electrically stimulated to perform exercise similar to that in the human experiments. A change in tendon organ signalling will be taken to mean that similar changes in humans could be responsible for disturbances of force sense. In further experiments, the mechanism of the changes will be explored.

这是一个共同的经验，被携带的物体感觉更重，需要肌肉努力的任务变得更加困难，因为一个人变得疲惫，肌肉疲劳在用力。肌肉力量的感觉取决于两个因素。一种是对完成一项任务所需努力的感觉，这种感觉是在中枢神经系统中产生的。另一种是肌肉产生的力量感，它是由一种叫做高尔基腱器官的感觉受体发出的信号在肌肉中产生的。肌肉力量的感觉和物体的重量是两种感觉结合的结果，但每一种感觉的贡献是未知的。该项目的目的是确定疲劳肌肉中的力觉干扰是否是由于肌腱器官发出肌肉产生的实际力的信号的方式发生了变化。这对于理解力觉在运动后和疾病状态下是如何被干扰的，以及理解肌肉力量在日常情况下的正常感知方式都很重要。通过要求人类受试者在仅锻炼一个肢体之前和之后在双臂或双腿中产生他们认为相等的力，来记录锻炼后的力觉障碍。力估计的误差将表现为两个肢体之间的不匹配。人体实验的困难在于，肌腱器官产生的信号无法直接测量，只能推断，而且可能是错误的。这一困难将通过直接测量麻醉动物的肌腱器官活动来克服，其中肌肉将被电刺激以进行类似于人体实验中的运动。肌腱器官信号的变化意味着人类的类似变化可能是力觉干扰的原因。在进一步的实验中，将探索这些变化的机制。