A stem cell-specific microRNA-independent function of Drosha

Drosha 的干细胞特异性、独立于 microRNA 的功能

• 批准号: nhmrc : 1122384
• 负责人: Dr Mark Chong
• 金额: $ 39.43万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stem-cell-specific-function-drosha/946948
• 关键词: stem; cell; specific; microRNA; independent

Stem cells are responsible for producing and replenishing the ~200 specialised cell types in our body. Our goal is to understand the molecular switches that control the function of these cells. We recently discovered that the activity of certain genes within stem cells is controlled by degradation. This degradation is absolutely crucial for safeguarding the function of stem cells. This project will investigate how this novel mechanism is controlled within these cells.

干细胞负责产生和补充我们体内约200种特殊的细胞。我们的目标是了解控制这些细胞功能的分子开关。我们最近发现，干细胞内某些基因的活性受降解的控制。这种降解对于保障干细胞的功能是绝对关键的。这个项目将研究这种新的机制是如何在这些细胞中控制的。