MicroRNA networks that safeguard the functional program of regulatory T cells

保护调节性 T 细胞功能程序的 MicroRNA 网络

• 批准号: nhmrc : 637338
• 负责人: Dr Mark Chong
• 金额: $ 30.54万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microrna-networks-safeguard-t-cells/96261
• 关键词: MicroRNA; networks; safeguard; functional; program

A newly discovered group of molecules termed microRNAs are thought to function as rheostats for the activity of genes. We have shown that these molecules are critical for the function of an immune cell type termed regulatory T cells. Without these cells, the immune system is unable to prevent uncontrolled and destructive inflammation. This proposal aims to utilize diverse technologies to uncover the precise molecular mechanisms by which microRNAs safeguard the function of regulatory T cells.

一组新发现的称为microRNA的分子被认为对基因的活性起着变阻器的作用。我们已经表明，这些分子对于称为调节性T细胞的免疫细胞类型的功能至关重要。如果没有这些细胞，免疫系统就无法防止不受控制的破坏性炎症。该提案旨在利用不同的技术来揭示microRNA保护调节性T细胞功能的精确分子机制。