MicroRNA networks that safeguard the functional program of regulatory T cells

一组新发现的分子被称为microrna，被认为是基因活性的变阻器。我们已经证明，这些分子对一种称为调节性T细胞的免疫细胞的功能至关重要。没有这些细胞，免疫系统就无法阻止不受控制的破坏性炎症。本研究旨在利用多种技术揭示microrna保护调节性T细胞功能的精确分子机制。

A newly discovered group of molecules termed microRNAs are thought to function as rheostats for the activity of genes. We have shown that these molecules are critical for the function of an immune cell type termed regulatory T cells. Without these cells, the immune system is unable to prevent uncontrolled and destructive inflammation. This proposal aims to utilize diverse technologies to uncover the precise molecular mechanisms by which microRNAs safeguard the function of regulatory T cells.